If you ever received a consent form mere hours or minutes before a hospital procedure, you can imagine how confused the mother was when she received a form asking her to agree to let one of her unborn twins participate in Dr. He Jiankui's gene-editing experiment. Relying on information learned from Dr. Michael Deem, his U.S. Ph.D. mentor, Dr. He used the CRISPR-Cas9 technique to disable the gene that enables HIV to enter a cell by attaching itself to a protein.
Medical professionals cannot be expected to write informed consent forms lay people can understand. Communication experts in the countries where forms are used need to choose the best ways to translate modern medical research and procedures and to pilot test forms before they are used.
Since drugs produced in one country are used and sold at different prices throughout the world, they have the potential to be weaponized by overpricing them for, or withholding them from, enemy countries.
Other practices also require attention. Some countries and companies offer financial rewards for stealing intellectual property.
The FBI is investigating Yu Zhou for making millions by forming a company based on a discovery he made while using U.S. government grants and performing research owned by Ohio's National Children;s Hospital while he worked in a lab there for ten years.
In a major example of "ethics dumping," the practice of performing a medical procedure in another country that is banned at home, China's health ministry prevented Italian neurosurgeon, Dr. Sergio Canavero, from attaching the head of a paralyzed patient to the body of a deceased donor in China.
When a doctor suggests a child take a prescribed drug or undergo a procedure, does the child's parent or guardian truly understand the side effects and alternatives? Modern medicine is not only costly; it is complicated. Busy adults often lack time to obtain a second opinion, ask a pharmacist if there is a lower cost generic, analyze internet opinions, or subscribe to and read a newsletter from a medical research center. At the very least, a relationship with a child's doctor and specialists needs to feel comfortable enough to ask questions and follow-up questions to make answers clear. As soon as children are old enough, involve
them in the questioning. They want to know if a needle or the dentist will hurt and how long they will be in the hospital or have to wear a cast or braces.
Teachers, scouting groups, boys and girls clubs, etc. might look for opportunities to assign reports on subjects, such as gene editing, bioethics, using drones to deliver drugs in Africa, hair growth products, vaccines, and vaping. Also, see if the Red Cross, nursing organizations, emergency medical services, local hospitals, or other medical associations have outreach programs that provide speakers and tours.
Students always ask how what they are supposed to learn is relevant. Everywhere in the world learning about health is relevant.
Showing posts with label CRISPR-Cas9. Show all posts
Showing posts with label CRISPR-Cas9. Show all posts
Monday, October 7, 2019
Friday, January 18, 2019
The AI Rush to Unemployment
China, the United States, Vietnam, South Korea, and Europe are rushing to replace human intelligence with artificial intelligence (AI). Recent magazine articles try to reassure readers that they need not fear being replaced by robots, but the evidence is far from conclusive.
An article in The Economist magazine (January 12, 2019) claimed China can cushion falling employment in export-related industries and its tech sector by increasing jobs in labor-intensive services "from restaurants to couriers." But the December 2018/January 2019 issue of the AARP magazine arrived with news that the vending machine business grew 26% in 2018. Sales went up once machines began accepting payments for beverages and snacks by processing credit cards and other cashless payments. The same magazine also touted the "Starship delivery robot," tested in 100 cities around the world, that uses cameras and sensors, not couriers, to avoid traffic by using sidewalks to deliver meals.
According to "The Truth about Robots," an article in TIME magazine (February 4-11, 2019), AI will not replace some jobs: creative jobs performed by inventors, scientists, novelists, artists; complex, strategic jobs of executives, diplomats, economists; and empathetic and compassionate jobs of teachers, nannies, and doctors. Considering there are a limited number of these positions, automation is making inroads into many of them, and others are low-paid, I am not reassured.
AI tells consumers, if you like that, you'll also like this. It suggests more things to buy but not more ways to make money to buy them. Unemployment raises the specter of modern Luddites, civil unrest, and fear of death by unmanned weapons attacking from land, sea, and space. Jobless, frightened humans are going to protest at home, to cause refugee disease and terrorist problems when they migrate to look for work elsewhere, and to prove vulnerable to scams.
Retraining the workforce seems a key path to the future. When executives in any field spot a new direction their business is going, trendwatching.com suggests they form alliances with academic institutions to help teachers train students for future opportunities. The 3M company, for example, created a free, 110-hour college course to help teachers prepare elementary and middle school students for a science competition that opened young eyes to future careers.
At the very least, countries need to focus on educating the public. Left to themselves, the untethered elite will go on blissfully making fortunes and inventing and doing things without considering the consequences as a helpless majority stands by. John Gray's critique of modern secular humanism identifies the mismatch between the human need for income-producing employment and technology's rush to replace human labor. In his new book, Seven Types of Atheism, he writes, "The cumulative increase of knowledge in science has no parallel in ethics or politics, philosophy or the arts."
There was a time when well-educated folks looked out at the world and decided they could help the sick with "Doctors without Borders" or field a Peace Corps to teach all sorts of skills. Dr. Lorna Hahn organized an association that brought together newly-independent countries with experts who knew how to do things like write constitutions.-
We are at a crossroads, where humanity needs the wisdom, for example, to use CRISPR-Cas9 technology to develop uniform crops machines can harvest to feed the human race, while refraining from using CRISPR-Cas9 technology to edit genes that can eliminate all or part of the human race. (Also see the earlier post, "The Where Did I Come From? Game.") We need experts with ideas about how to engage the billions of workers robots are rushing to replace.
An article in The Economist magazine (January 12, 2019) claimed China can cushion falling employment in export-related industries and its tech sector by increasing jobs in labor-intensive services "from restaurants to couriers." But the December 2018/January 2019 issue of the AARP magazine arrived with news that the vending machine business grew 26% in 2018. Sales went up once machines began accepting payments for beverages and snacks by processing credit cards and other cashless payments. The same magazine also touted the "Starship delivery robot," tested in 100 cities around the world, that uses cameras and sensors, not couriers, to avoid traffic by using sidewalks to deliver meals.
According to "The Truth about Robots," an article in TIME magazine (February 4-11, 2019), AI will not replace some jobs: creative jobs performed by inventors, scientists, novelists, artists; complex, strategic jobs of executives, diplomats, economists; and empathetic and compassionate jobs of teachers, nannies, and doctors. Considering there are a limited number of these positions, automation is making inroads into many of them, and others are low-paid, I am not reassured.
AI tells consumers, if you like that, you'll also like this. It suggests more things to buy but not more ways to make money to buy them. Unemployment raises the specter of modern Luddites, civil unrest, and fear of death by unmanned weapons attacking from land, sea, and space. Jobless, frightened humans are going to protest at home, to cause refugee disease and terrorist problems when they migrate to look for work elsewhere, and to prove vulnerable to scams.
Retraining the workforce seems a key path to the future. When executives in any field spot a new direction their business is going, trendwatching.com suggests they form alliances with academic institutions to help teachers train students for future opportunities. The 3M company, for example, created a free, 110-hour college course to help teachers prepare elementary and middle school students for a science competition that opened young eyes to future careers.
At the very least, countries need to focus on educating the public. Left to themselves, the untethered elite will go on blissfully making fortunes and inventing and doing things without considering the consequences as a helpless majority stands by. John Gray's critique of modern secular humanism identifies the mismatch between the human need for income-producing employment and technology's rush to replace human labor. In his new book, Seven Types of Atheism, he writes, "The cumulative increase of knowledge in science has no parallel in ethics or politics, philosophy or the arts."
There was a time when well-educated folks looked out at the world and decided they could help the sick with "Doctors without Borders" or field a Peace Corps to teach all sorts of skills. Dr. Lorna Hahn organized an association that brought together newly-independent countries with experts who knew how to do things like write constitutions.-
We are at a crossroads, where humanity needs the wisdom, for example, to use CRISPR-Cas9 technology to develop uniform crops machines can harvest to feed the human race, while refraining from using CRISPR-Cas9 technology to edit genes that can eliminate all or part of the human race. (Also see the earlier post, "The Where Did I Come From? Game.") We need experts with ideas about how to engage the billions of workers robots are rushing to replace.
Wednesday, January 9, 2019
The "Where Did I Come From?" Game
Not only do genes influence the color of our eyes and other physical characteristics, but findings, reported in Blueprint: How DNA Makes Us Who We Are by Robert Plomin, indicate genes also have an impact on our behavior.
In other words, besides influencing a person's height, genetics also can have more to do with a person's plans to attend college than a household environment filled with books. Genetic tests that purport to measure innate abilities, however, do not predict if a person will find, make, or choose a way to activate an innate trait by, for example, actually attending and graduating from college.
The realization that genetics have an impact on both body and behavior raises even greater concern about using the CRISPR-Cas9 technique to edit human genes, something that it appears Chinese researcher, He Jiankui, already has done. In contrast, what the Seleggt egg-producing company in Germany is doing, according to trendwatching.com, is very worthwhile. Seleggt is identifying the sex of male check eggs before they hatch, using the eggs for fertilizer, and eliminating previous inhumane methods of killing about 4.6 billion male chickens every year.
Editing affects not just one person's DNA; changes are passed on from generation to generation.That is all well and good, if, for example, an entire family tree inherits immunity to an infection. But mutation of a chosen gene, however well intended to be beneficial, might also cause mutation in non-targeted genes and other undesirable changes, such as deletion of sections of DNA, in the mix of chromosomes that make up a human person.
The added realization that genes affect behavioral traits as well as physical ones means using CRISPR-Cas9 to change human genes is all the more irresponsible.
My father used to say, "There are no fat Jautzes." Photos of relatives show whether he was right or wrong. They also show where my sister got her red hair. Just as Carl Zimmer wrote in She Has Her Mother's Laugh, we also should pay close attention to family histories of medical problems, such as fractured bones, we might share with ancestors. Looking at traits inherited from members of our family tree explains why our current generation has entrepreneurs, writers, actors, musicians, and only one scientist. In Vogue (March, 2019), I also noticed the Armenian-Syrian singer and composer, Karyyn, reported, "All of my aunts and uncles in Syria on my mom's side are artists, singers, musicians, and puppeteers."
A young person trying to decide on a career can begin by finding out the professions their ancestors chose. On the PBS TV show that helps prominent people discover their roots, politicians often are amazed to learn of relatives who also were public servants.
Playing "Where Did I Come From?" is fun. But, unless carefully played, using gene editing to change pieces becomes a very dangerous game.
In other words, besides influencing a person's height, genetics also can have more to do with a person's plans to attend college than a household environment filled with books. Genetic tests that purport to measure innate abilities, however, do not predict if a person will find, make, or choose a way to activate an innate trait by, for example, actually attending and graduating from college.
The realization that genetics have an impact on both body and behavior raises even greater concern about using the CRISPR-Cas9 technique to edit human genes, something that it appears Chinese researcher, He Jiankui, already has done. In contrast, what the Seleggt egg-producing company in Germany is doing, according to trendwatching.com, is very worthwhile. Seleggt is identifying the sex of male check eggs before they hatch, using the eggs for fertilizer, and eliminating previous inhumane methods of killing about 4.6 billion male chickens every year.
Editing affects not just one person's DNA; changes are passed on from generation to generation.That is all well and good, if, for example, an entire family tree inherits immunity to an infection. But mutation of a chosen gene, however well intended to be beneficial, might also cause mutation in non-targeted genes and other undesirable changes, such as deletion of sections of DNA, in the mix of chromosomes that make up a human person.
The added realization that genes affect behavioral traits as well as physical ones means using CRISPR-Cas9 to change human genes is all the more irresponsible.
My father used to say, "There are no fat Jautzes." Photos of relatives show whether he was right or wrong. They also show where my sister got her red hair. Just as Carl Zimmer wrote in She Has Her Mother's Laugh, we also should pay close attention to family histories of medical problems, such as fractured bones, we might share with ancestors. Looking at traits inherited from members of our family tree explains why our current generation has entrepreneurs, writers, actors, musicians, and only one scientist. In Vogue (March, 2019), I also noticed the Armenian-Syrian singer and composer, Karyyn, reported, "All of my aunts and uncles in Syria on my mom's side are artists, singers, musicians, and puppeteers."
A young person trying to decide on a career can begin by finding out the professions their ancestors chose. On the PBS TV show that helps prominent people discover their roots, politicians often are amazed to learn of relatives who also were public servants.
Playing "Where Did I Come From?" is fun. But, unless carefully played, using gene editing to change pieces becomes a very dangerous game.
Wednesday, November 16, 2016
The Challenge of New Technologies: Prepare to Think
IBM recognized what the future would require by showing the lack of space planned for the "K" slipping down the side of its "THINK" signs. The need to think was on display at last night's poster and presentation session given by high school students who spent their summer in science labs and departments at the University of Wisconsin.
Students needed to be willing to expend a major effort just preparing for their experiments. One young woman dragged branches, plants, and flowers to the lab to find that birds need to be motivated by an attractive, secure area in order to breed. Multiple times a young man rowed a boat into the middle of a lake at night in order to scoop up water that showed what destroyed undesirable algae multiplied faster than the invasive species that destroyed the helpful algae remover. Another student had to find a sausage factory where he could procure the pig livers he needed to test how their properties changed during heating in a microwave. Various purifying procedures were needed before testing and careful math calculations were needed before a machine could emit radiation to attack tumors. Findings, such as the dangers of the toxic nano particles lithium batteries give off as they decompose, were preliminary but important.
Heading into the future, artificial intelligence (AI); robotics, CRISPR and other medical technologies; the relationship of technology, human values, and public policy; and other technical subjects will play a major role in lives throughout the world. Yet in recent elections, electorates have cast their votes based on emotion: anger about the rich who are getting richer while they're not, anger about their countries filling up with people who don't look like them, and anger about a perceived attack on their values.
Away from the disillusioned voters back home, members of the World Economic Forum (weforum.org) met in Dubai, United Arab Emirates, this week to discuss the impact of new technologies. Their discussions need to make it back home to those have to understand how they will be affected by the good and bad impacts these technologies will have on their lives.
However, you can't help but sympathize with anyone who tries to deal with the complexity and scientific jargon in an article about a technology, such as CRISPR-Cas9. First there is a description. CRISPR-Cas9 can genetically edit cells to improve crops and fight disease. In humans, if used to alter the genetic make-up of cells in an egg, sperm, or embryo, the same mutation will be transmitted from generation to generation. In order for the latter process to work, genes injected from outside need to be accepted by cells that store the germline, the biochemical unit of heredity.
Then, articles tout the benefits of the new technology. Pig organs could be produced without the genes that prevent transplants in humans. Malaria-carrying mosquitoes could be eliminated the way genetically altered Atlantic salmon already grow double the size of ordinary salmon in half the time. Diseases could be cured, even though the complex interrelationship of genes often makes this unlikely in many cases.
Articles frequently ignore problems associated with new technologies. It is up to the reader to ask, "Couldn't a rogue scientist use CRISPR-Cas9 to inject unhealthy mutations into human cells that would be transmitted from generation to generation?" Or might only wealthy people be able: to afford the cures that CRISPR-Cas9 technology could provide. While CRISPR-altered seeds produce uniform crops that can be harvested by machines, farmers in poor countries may not be able to pay for the annual purchase of patented hybrid seeds that grow food in drought conditions.
Some call the biomedical duel between China and the United States to achieve dramatic CRISPR-Cas9 results "Sputnik 2.0." On October 18, 2016 scientists at Sichuan University in Chengdu, China, used CRISPR-Cas9 technology to see whether they could disable a gene in the patient's immune cells and reprogram the lung cancer patient's cells not only to resist but to fight back against the cancer. To date, results of the test are not known and neither are side effects. At the University of Pennsylvania in Philadelphia, Dr. Carl June also is about to use CRISPR editing to enable three genes in the immune cells of 18 cancer patients, who have not been helped by other treatments, to seek and destroy their cancerous tumors.
Guarding against technology bias also needs to keep up with fast-paced artificial intelligence (AI) developments. Joy Buolamwini's Algorithmic Justice League found facial-analysis software was prone to making mistakes recognizing the female gender, especially of darker-skinned women. AI is developed by and often tested primarily on light-skinned men, but recognition technology, for example, is promoted for hiring, policing, and military applications involving diverse populations.
Finally, we all need to think about and act on the guidelines, regulations, and other checks needed to keep up with the effects of rapidly progressing new technologies.
Students needed to be willing to expend a major effort just preparing for their experiments. One young woman dragged branches, plants, and flowers to the lab to find that birds need to be motivated by an attractive, secure area in order to breed. Multiple times a young man rowed a boat into the middle of a lake at night in order to scoop up water that showed what destroyed undesirable algae multiplied faster than the invasive species that destroyed the helpful algae remover. Another student had to find a sausage factory where he could procure the pig livers he needed to test how their properties changed during heating in a microwave. Various purifying procedures were needed before testing and careful math calculations were needed before a machine could emit radiation to attack tumors. Findings, such as the dangers of the toxic nano particles lithium batteries give off as they decompose, were preliminary but important.
Heading into the future, artificial intelligence (AI); robotics, CRISPR and other medical technologies; the relationship of technology, human values, and public policy; and other technical subjects will play a major role in lives throughout the world. Yet in recent elections, electorates have cast their votes based on emotion: anger about the rich who are getting richer while they're not, anger about their countries filling up with people who don't look like them, and anger about a perceived attack on their values.
Away from the disillusioned voters back home, members of the World Economic Forum (weforum.org) met in Dubai, United Arab Emirates, this week to discuss the impact of new technologies. Their discussions need to make it back home to those have to understand how they will be affected by the good and bad impacts these technologies will have on their lives.
However, you can't help but sympathize with anyone who tries to deal with the complexity and scientific jargon in an article about a technology, such as CRISPR-Cas9. First there is a description. CRISPR-Cas9 can genetically edit cells to improve crops and fight disease. In humans, if used to alter the genetic make-up of cells in an egg, sperm, or embryo, the same mutation will be transmitted from generation to generation. In order for the latter process to work, genes injected from outside need to be accepted by cells that store the germline, the biochemical unit of heredity.
Then, articles tout the benefits of the new technology. Pig organs could be produced without the genes that prevent transplants in humans. Malaria-carrying mosquitoes could be eliminated the way genetically altered Atlantic salmon already grow double the size of ordinary salmon in half the time. Diseases could be cured, even though the complex interrelationship of genes often makes this unlikely in many cases.
Articles frequently ignore problems associated with new technologies. It is up to the reader to ask, "Couldn't a rogue scientist use CRISPR-Cas9 to inject unhealthy mutations into human cells that would be transmitted from generation to generation?" Or might only wealthy people be able: to afford the cures that CRISPR-Cas9 technology could provide. While CRISPR-altered seeds produce uniform crops that can be harvested by machines, farmers in poor countries may not be able to pay for the annual purchase of patented hybrid seeds that grow food in drought conditions.
Some call the biomedical duel between China and the United States to achieve dramatic CRISPR-Cas9 results "Sputnik 2.0." On October 18, 2016 scientists at Sichuan University in Chengdu, China, used CRISPR-Cas9 technology to see whether they could disable a gene in the patient's immune cells and reprogram the lung cancer patient's cells not only to resist but to fight back against the cancer. To date, results of the test are not known and neither are side effects. At the University of Pennsylvania in Philadelphia, Dr. Carl June also is about to use CRISPR editing to enable three genes in the immune cells of 18 cancer patients, who have not been helped by other treatments, to seek and destroy their cancerous tumors.
Guarding against technology bias also needs to keep up with fast-paced artificial intelligence (AI) developments. Joy Buolamwini's Algorithmic Justice League found facial-analysis software was prone to making mistakes recognizing the female gender, especially of darker-skinned women. AI is developed by and often tested primarily on light-skinned men, but recognition technology, for example, is promoted for hiring, policing, and military applications involving diverse populations.
Finally, we all need to think about and act on the guidelines, regulations, and other checks needed to keep up with the effects of rapidly progressing new technologies.
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